Table 2.
Matrix metalloproteinases that expressed and degrade collagen during cutaneous wound healing
| Group | MMP | Cells source | Substrates |
|---|---|---|---|
| Collagenases | MMP-1 | Proliferating and migrating keratinocytes fibroblasts | Collagens I, II, III, V, VII, X, XI; gelatines |
| MMP-8 | Neutrophils | Collagens I, II, III, VII, VIII, X | |
| Gelatines | |||
| MMP-13 | Fibroblasts | Collagens I, II, III, IV, IX, X, XIV | |
| Migrating keratinocytes | |||
| Gelatinases | MMP-2 | Fibroblasts | Gelatines |
| Keratinocytes | Collagens III, IV, V, VII, X, XI, XIV | ||
| Endothelial cells | |||
| Macrophages | |||
| MMP-9 | Keratinocytes | Gelatines | |
| Neutrophils | Collagens I, IV, V | ||
| Macrophages | |||
| Endothelial cells | |||
| Stromelysins | MMP-3 | Basal proliferating keratinocytes | Collagens I, III, IV, V, IX, X |
| Fibroblasts | Gelatines | ||
| MMP-10 | Migrating keratinocyte | Collagens I, III, IV, V, IX, X | |
| Fibroblasts | Gelatines | ||
| Metalloelastase | MMP-12 | Macrophages | Collagen IV; gelatines |
| Membrane type MMP | MMP-14 | Migrating keratinocytes | Collagen I, II, III |
| (MT1-MMP) | Gelatines | ||
| Other MMPs | MMP-19 | Keratinocyte | Gelatines |
| Fibroblast | Collagen IV | ||
| Endothelial cells |
MMPs, matrix metalloproteinases.