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. Author manuscript; available in PMC: 2015 Sep 6.
Published in final edited form as: Nat Commun. 2015 Mar 6;6:6302. doi: 10.1038/ncomms7302

Figure 1.

Figure 1

Association between molecular and clinicopathological features of pediatric adrenocortical tumors. (a) Upper panel: clinicopathological features of 19 patients in the WGS cohort. Center panel: genetic alterations, including mutational status of TP53 (R337H identified by asterisk), ATRX and CTNNB1; telomere length; number of structural variations (SVs); background mutation rate (BMR); chromothripsis and kataegis. Und: undetermined malignancy. Lower panel: RNA expression of selected genes involved in chromosomal segregation and cell cycle control. Three distinct tumor groups (labeled below) emerged from this analysis. Control: normal adrenocortical tissue. (b) Kaplan-Meier probability of event-free survival (exact log-rank test) of pediatric ACT patients in group 1 vs. others.