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. Author manuscript; available in PMC: 2015 Mar 9.
Published in final edited form as: Synlett. 2014;26(3):335–339. doi: 10.1055/s-0034-1379015

Table 1.

Optimization of Reaction Conditions

graphic file with name nihms-618846-t0004.jpg
entry [Cu] (mol %) TEMPO (mol %) yield 2aa
1 Cu(eh)2 (15) - 28%
2 Cu(eh)2 (20) 50 41%b
3 Cu(OTf)2•3 (20) 50 65%c
4 Cu(OTf)2•4(20) 50 65%c
5 Cu(eh)2 (20) 20 73%
6 Cu(eh)2 (15) 20 71%
7 Cu(eh)2 (15) 10 40%c
8 - 20 NR
a

Isolated yield.

b

20% of 2aa was also isolated.

c

Conversion % based on crude 1H NMR.

Cu(eh)2 = copper(II) 2-ethylhexanoate, NR = No reaction