Table 3.

Validated human cell lines used in Barrett’s esophagus and esophageal adenocarcinoma research

Cell Line	Type	Background	Ref
EPC2-hTert	INE	Squamous esophageal epithelium from male non-BE patient–immortalized by hTERT	(50, 51).
HET1A	INE	Squamous esophageal epithelium–immortalized by SV40 virus Large T antigen	(50, 60, 61)
NES-B3T	INE	Squamous esophageal epithelium from BE patient– immortalized by hTERT	(50, 51).
NES-G2T	INE	Squamous esophageal epithelium from non-BE patient–immortalized by hTERT	(50, 51).
BAR-T	IBE	hTERT immortalized non dysplastic Barrett’s esophagus from a 69 year-old male	(52)
CP-A	IBE	hTERT immortalized non dysplastic Barrett’s esophagus	(53)
CP-B	IBE	hTERT immortalized dysplastic Barrett’s esophagus	(53)
CP-C	IBE	hTERT immortalized dysplastic Barrett’s esophagus	(53)
CP-D	IBE	hTERT immortalized dysplastic Barrett’s esophagus	(53)
ESO26	EAC	Established from a 51 year-old Caucasian male with a primary tumor located at the gastroesophageal junction and distal esophagus with known lymph node and distant metastases.	(48, 49)
ESO51	EAC	Established from a 74 year-old Caucasian male with a primary adenocarcinoma of the distal esophagus and Barrett’s esophagus.	(48, 49)
FLO-1	EAC	Established from a primary distal esophageal adenocarcinoma in a 68 year-old Caucasian male.	(48, 49)
JH-EsoAd1	EAC	Established from a distal esophageal adenocarcinoma (moderately to poorly differentiated) within Barrett’s esophagus.	(48, 49)
KYAE-1	EAC	Established from the pleural effusion from a from a 60 year old Asian male with a distal esophageal adenocarcinoma.	(48, 49)
OACM5.1	EAC	Established from a lymph node metastasis from a 47 year-old Caucasian female with primary adenocarcinoma of distal esophagus and Barrett’s esophagus. The patient also exhibited pleural metastases.	(74)
OACP4C	EAC	Established from a primary gastric cardia tumor in a 55 year-old Caucasian male. The patient also exhibited lymph node and pleural metastases.	(48, 49)
OE19	EAC	Also known as JROECL19, was established from a well-differentiated adenocarcinoma of gastric cardia/esophageal gastric junction of a 72 year old male patient.	(75)
OE33	EAC	Also known as JROECL33, was established from a poorly differentiated adenocarcinoma of the lower esophagus with Barrett’s metaplasia from a 73 year old female patient.	(75)
SK-GT-4	EAC	Established from a primary well-differentiated adenocarcinoma arising in the distal esophagus within Barrett esophagus of an 89 year-old Caucasian male.	(76)

INE: immortalized normal esophagus; IBE: immortalized Barrett’s esophagus; EAC: Esophageal adenocarcinoma; hTERT: human telomerase gene;