Table 2.
Left ventricular pump function and microelectrode parameters following resveratrol administration to control (WKY + Res) and diabetic rats (STZ + Res).
| Parameter | WKY | WKY + Res | SHR/STZ | SHR/STZ + Res |
|---|---|---|---|---|
| Diastolic stiffness | 23.7 ± 0.7 | 22.9 ± 0.9 | 26.1 ± 0.9# | 21.3 ± 0.9† |
| +dP/dTmax (mmHg/sec) | 2025 ± 115 | 2256 ± 138 | 1488 ± 211# | 2200 ± 116† |
| −dP/dTmax (mmHg/sec) | −1206 ± 97 | −1394 ± 118 | −887 ± 131# | −1440 ± 82† |
| Developed pressure (mmHg) | 112.6 ± 5.6 | 124.0 ± 7.4 | 84.6 ± 11.5# | 103.8 ± 8.6 |
| End systolic pressure (mmHg) | 120.0 ± 6.2 | 134.1 ± 7.2 | 96.2 ± 11.7 | 114.8 ± 9.1 |
| Action potential duration at 20% of repolarisation (msec) | 18.7 ± 0.9 | 20.6 ± 0.7 | 35.6 ± 1.8# | 29.4 ± 1.9† |
| Action potential duration at 50% of repolarisation (msec) | 28.7 ± 1.2 | 31.2 ± 1.4 | 66.3 ± 2.4# | 46.8 ± 4.3† |
| Action potential duration at 90% of repolarisation (msec) | 58.8 ± 3.2 | 66.7 ± 6.1 | 123.6 ± 9.2# | 89.4 ± 6.6† |
| Resting membrane potential (mV) | −65.0 ± 2.1 | −67.1 ± 1.7 | −59.1 ± 2.0 | −61.1 ± 3.0 |
| Force of contraction (mN) | 2.6 ± 0.7 | 2.7 ± 0.4 | 1.7 ± 0.3 | 1.8 ± 0.3 |
Values are presented as mean ± SEM. # P < 0.05 versus WKY, † P < 0.05 versus SHR/STZ.