Fig. 5.
The combination of ibrutinib and anti–PD-L1 resulted in a long-term antitumor memory of the cured animals. Mice cured from C26 colon cancer were rechallenged s.c. 90 d later in the left side of their abdomen with 1 × 106 CT26 (n = 4 mice per group) or 20,000 4T1-Luc cells (n = 4 mice per group). As a control, naïve mice were also inoculated with the same cells (n = 8 mice per group). (Left) Tumor growth following 4T1-Luc or CT26 cell inoculation. Pictures were taken on day 17 post rechallenge. (Right) Tumor growth curve following the rechallenge; error bars indicate SEM P < 0.0001.