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Comparison of models of Wnt signaling. (A) Schematic of the new shuttle model in the absence (Left) and presence (Right) of a Wnt stimulus. DC and Dsh exist in inactive (i) and active (a) forms. P: phosphatase. For a full description of the reactions specifying this model, see SI Appendix. (B) Comparison of models: the shuttle model is compared with four others from literature (5–8) based on the features that are present–absent in each model.
