Fig. 3.

AM NPs demonstrated sustained blood circulation and minimal organ accumulation. (A) M₁₂PEG was administered in vivo to ApoE^−/− mice over a four-dose regimen for evaluation of whole body and organ biodistribution and serum pharmacokinetics. NPs had rapid, homogenous distribution and long serum half-lives after injection time points (arrows). Ex vivo fluorescence images (B, Left) and quantification (Right) show minimal organ accumulation with M₁₂PEG, with some residual NPs in the liver. Error bars represent SEM and n = 5. *P < 0.05 from the control (NT). Biodistribution and pharmacokinetics for control PS₁₄PEG NP treatment can be found in SI Appendix, Fig. S8.