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. 2015 Mar 9;5:8854. doi: 10.1038/srep08854

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(a) Typical immunohistochemical labeling profiles of (P)RR in PDAC tissues. (b) (P)RR expression in PanIN-1 and PanIN-2 lesions in representative pancreatic tissue samples. The PanIN-2 lesions show strong (P)RR immunoreactivity in the cytoplasm, although the PanIN-1 lesions show only focal and faint (P)RR staining. (c) (P)RR expression in normal pancreatic duct (NL), and PanIN-1 and PanIN-3 lesions in representative pancreatic tissue samples. The PanIN-3 lesions show strong (P)RR immunoreactivity in the cytoplasm. (d) Protein expression of full-length (P)RR in cell lysates was measured in HPDE cells and six different PDAC cell lines. β-actin was used as a loading control. Consistent results were observed when three experiments were repeated.