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. 2015 Mar 9;5:8854. doi: 10.1038/srep08854

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(a) Top: (P)RR expression and WST-1 proliferation assay in (P)RR siRNA-transfected PK-1 cells evaluated at 48 h after Wnt3a stimulation. Middle: (P)RR expression and WST-1 proliferation assay in (P)RR siRNA-transfected BxPC-3 cells evaluated at 48 h after Wnt3a stimulation. Bottom: (P)RR expression and WST-1 proliferation assay in (P)RR siRNA-transfected PANC-1cells evaluated at 48 h after Wnt3a stimulation. (b) Effect of (P)RR siRNA transfection on number of cells, as assessed by direct cell counting of Wnt3a-treated PK-1 cells. Wnt3a significantly increased the number of PK-1 cells. (P)RR siRNA treatment prevented the Wnt3a-induced the increase in number of cells. *P < 0.05 vs. scrambled siRNA cells; §P < 0.05 vs. vehicle-treated cells without Wnt3a stimulation; #P < 0.05 vs. scrambled siRNA-treated cells without Wnt3a stimulation; ¶P < 0.05 vs. (P)RR siRNA cells without Wnt3a stimulation. (c) Representative xenograft formation in vivo of scrambled siRNA-(left) or (P)RR siRNA-(right) transfected PANC-1 cells at four weeks postinjection. (d) Average tumor volume 25 days (left) and 40 days (right) after injected with scrambled siRNA- or (P)RR siRNA-transfected PANC-1 cells (mean ± SEM, n = 7, *P < 0.0001).