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. 2015 Mar;25(3):328–337. doi: 10.1101/gr.175240.114

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© 2015 Watanabe et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Allele-specific methylation analysis of the tumor (T) and adjacent nontumor (ADJ) sample genomes. The methylation levels of the HBV and human genomes for the integrated and unintegrated alleles in four paired tumor and adjacent nontumor samples (sample nos. 7–10) are shown. Detailed results of the HBV integrants (PreC, Precore; C, Core; PreS, Presurface; S, Surface; X, X) and flanking host genomes (position, chromosome, location of the genome, and gene names) are shown. The HBV genome became significantly methylated when integrated into highly methylated human genome regions, but not when integrated into unmethylated human genome regions. (×) The desired quantitative methylation levels were not obtained because of technical difficulties with the sequences that were being analyzed.