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. 2015 Mar;25(3):445–458. doi: 10.1101/gr.185579.114

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© 2015 Hoskins et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Myosin 81F links five Release 6 sequence scaffolds in pericentric heterochromatin. (A) The cDNA MIP31562 defines a new gene Myosin 81F that spans >2.5 Mb in the pericentric heterochromatin of chromosome arm 3R. The cDNA sequence was used in assembling five Release 5 BAC contigs, three unmapped (white boxes) and two on 3RHet (shaded boxes), into a series of five ordered and oriented Release 6 sequence scaffolds (Supplemental Fig. S14, 3RHet.9–13). Four unsized clone gaps between the scaffolds are indicated by double diagonal lines and map within introns of the gene. MIP31562 is 6604 bp in length, and its genomic alignment defines 22 exons. (B) The long ORF of MIP31562 encodes a 2082-aa protein with a myosin motor domain, three IQ motifs, and two sets of MyTH4 (Myosin Tail Homology 4), Ubiquitin (UBQ), FERM (4.1 protein, Ezrin, Radixin, and Moesin), and PH-like (Pleckstrin Homology-like) domains. The UBQ and FERM domains together are known as the multidomain Band 4.1 (B41) (Sellers 2000).