Fig. 1.

White matter regions demonstrating a significant effect of pubertal status on mean diffusivity (MD). (A) A large single cluster of voxels from the mean skeleton was identified which showed a decrease in MD in the late puberty group compared with the early puberty group. 3D images in axial, sagittal and coronal dimensions, showing areas demonstrating a significant effect of puberty on MD (red), superimposed on 3D reconstruction of the mean white matter tract skeleton (purple). These images are superimposed onto a 2D brain slice in MNI space for orientation purposes at z = −2, z = −8 and y = −35. Images created using Slicer (www.slicer.org) (Fedorov et al., 2012). B) Conventional display of axial slices depicting mean skeleton regions demonstrating a significant effect of puberty (red), shown in MNI space on an MNI standard brain template (MNI z coordinates are indicated for each axial slice).