Tab. IX.
Antimuscarinics versus mirabegron (50 mg) comparison: change from baseline in the number of micturitions, incontinence episodes, urgency urinary incontinence episodes, occurrences of dry mouth and constipation [84]
| Antimuscarinics versus mirabegron 50 mg (Credibility interval 1.0) | ||||
|---|---|---|---|---|
| Mean change from baseline | More effective than mirabegron | Less effective than mirabegron | ||
| Medication and dosage | Credibility interval | Medication and dosage | Credibility interval | |
|
Micturitions
(24 hrs) |
Solifenacin 5 mg Solifenacin 10 mg Oxybutynin 10 mg Trospium 60 mg |
–0.24 –0.58 –0.05 –0.13 |
Tolterodine 4 mg Darifenacin 7.5 mg Darifenacin 15 mg Fesoterodine 4 mg Fesoterodine 8 mg |
0.15 0.07 0.16 0.07 0.14 |
| 26 studies 22 040 patients |
PLACEBO: | 0.70 | ||
|
Incontinence episodes
(24 hrs) |
Solifenacin 5 mg Solifenacin 10 mg |
–0.23 –0.24 |
Tolterodine 4 mg Darifenacin 7.5 mg Darifenacin 15 mg Fesoterodine 4 mg Fesoterodine 8 mg Oxybutynin 10 mg |
0.09 0.13 0.09 0.10 0.22 0.14 |
| 17 studies 13 101 patients |
PLACEBO: | 0.50 | ||
|
Urge urinary incontinence episodes
(24 hrs) |
Fesoterodine 4 mg Fesoterodine 8 mg Oxybutynin 10 mg Solifenacin 5 mg Solifenacin 10 mg Trospium 60 mg |
–0.08 –0.22 –0.28 –0.3 –0.4 –0.3 |
Tolterodine 4 mg Darifenacin 15 mg |
0.09 0.04 |
| 18 studies 16 044 patients |
PLACEBO: | 0.44 | ||
| Dry mouth | Medication and dosage | Odds ratio | Medication and dosage | Odds ratio |
| None | Tolterodine ER 4 mg Tolterodine IR 4mg Darifenacin 7.5 mg Darifenacin 15 mg Fesoterodine 4 mg Fesoterodine 8 mg Oxybutynin ER 5 mg Oxybutynin ER 10 mg Oxybutynin ER 15 mg Oxybutynin IR 10 mg Oxybutynin IR 9 mg Solifenacin 5 mg Solifenacin 10 mg Trospium 40 mg Trospium 60 mg |
4.23 7.3 5.20 8.4 4.6 9.98 4.22 7.05 8.16 14.63 11.17 4.21 10.30 5.97 4.85 |
||
| 44 studies 27 309 patients |
PLACEBO: | 1.34 | ||
| Constipation | None | Tolterodine ER 4 mg Tolterodine IR 4mg Darifenacin 7.5 mg Darifenacin 15 mg Fesoterodine 4 mg Fesoterodine 8 mg Oxybutynin ER 5 mg Oxybutynin ER 10 mg Oxybutynin ER 15 mg Oxybutynin IR 10 mg Oxybutynin IR 9 mg Solifenacin 5 mg Solifenacin 10 mg Trospium 40 mg |
1.10 1.02 1.72 3.15 1.06 1.91 2.45 1.01 2.16 1.55 0.99 2.38 4.24 1.69 |
|
| 41 studies 25 257 patients |
PLACEBO: | 0.73 | ||