Table 2.
Risk Factors Predicting Mobilization Failure*
| Univariate Analysis | Multivariate Analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| N | N failed |
% failed | OR | 95% CI | p | OR | 95% CI | p | |
| Total | 302 | 26 | 9% | ||||||
| Age | |||||||||
| ≤60 years | 171 | 11 | 6% | ||||||
| >60 years | 131 | 15 | 11% | 1.9 | 0.8–4.2 | 0.13 | |||
| Prior chemo regimens | |||||||||
| ≤1 | 186 | 9 | 5% | ||||||
| >1 | 115 | 17 | 15% | 3.4 | 1.5–7.9 | 0.004 | |||
| Previous radiation | |||||||||
| Yes | 90 | 9 | 10% | 1.3 | 0.5–2.9 | 0.6 | |||
| No | 212 | 17 | 8% | ||||||
| Interval between diagnosis and mobilization | |||||||||
| ≤12 months | 237 | 11 | 5% | ||||||
| >12 months | 65 | 15 | 23% | 6.1 | 2.7–14 | <0.001 | 4.6 | 1.9–11.1 | 0.001 |
| White blood cell count (× 109/Liter) | |||||||||
| ≤4 | 41 | 6 | 15% | ||||||
| >4 | 260 | 20 | 8% | 0.5 | 0.2–1.3 | 0.15 | |||
| ≤5.7 (median) | 152 | 17 | 11% | ||||||
| >5.7 | 149 | 9 | 6% | 0.5 | 0.2–1.2 | 0.1 | |||
| Platelet count (× 109/Liter) | |||||||||
| ≤262 (median) | 150 | 17 | 11% | ||||||
| >262 | 151 | 9 | 6% | 0.5 | 0.2–1.1 | 0.1 | |||
| ≤150 | 24 | 3 | 12% | ||||||
| >150 | 277 | 23 | 8% | 0.6 | 0.2–2.3 | 0.5 | |||
| Cellularity | |||||||||
| ≤30% | 137 | 11 | 8% | ||||||
| >30% | 164 | 14 | 8% | 1.1 | 0.5–2.4 | 0.9 | |||
| ≤35% (median) | 159 | 13 | 8% | ||||||
| >35% | 142 | 12 | 8% | 1 | 0.5–2.3 | 0.9 | |||
| Prior lenalidomide | |||||||||
| No | 238 | 10 | 4% | ||||||
| Yes | 64 | 16 | 25% | 7.6 | 3.2–18 | <0.001 | 5.9 | 2.4–14.3 | <0.001 |
| Year | |||||||||
| 2005 | 67 | 5 | 7% | ||||||
| 2006 | 137 | 7 | 5% | ||||||
| 2007 | 98 | 14 | 14% | 2.7 | 1.2–6 | 0.02 | |||
*
Totals vary because of unknown values of some characteristics for one patient