Table 3.
Outcomes of 14 Patients with Myelofibrosis and Leukemic Transformation Treated with Allogeneic Stem Cell Transplantation
Primary engraftment (%)* | 100% |
Engraftment (median, range) | |
Day to ANC 500 (N = 14) | 13 (8-21) |
Days to platelet count 20,000 (N = 11) | 21.5 (13-40) |
Chimerism at day 30 by PCR* (N = 14) | |
100% | 11 |
85%-99% | 2 |
Not tested | 1 |
Median follow-up survivors, months (range) | 31 (10-127) |
aGVHD, n | |
Grade II-IV | 5 |
Grade III-IV | 2 |
cGVHD, n | |
All grades | 5 |
Extensive | 2 |
Complete remission after transplant, n | 14 |
Disease progression | |
n (% CI) | 4 (38%) (16-89)† |
NRM, Overall | |
n (% CI) | 4 (29%) (12-65)† |
PFS, Overall | |
n (% CI) | 6 (33%) (7-63)† |
OS, Overall | |
n (% CI) | 7 (49%) (22-72)† |
ANC indicates absolute neutrophil count; PCR, polymerase chain reaction; aGVHD, acute graft-versus-host-disease; cGVHD, chronic graft-versus-host disease; NRM, nonrelapse mortality; PFS, progression-free survival; OS, overall survival; CI, cumulative incidence.
Donor myeloid and T cells.
95% Confidence interval.