Table 3.
Composition and physical characteristics of drug loaded nanocomposite microbeads.
| Formulation code | S. A | Neusilin US2 | Calcium chloride | Actual drug content | DEE |
|---|---|---|---|---|---|
| (%w/w) | (%w/w) | (%w/v) | (mg/50 mg) | (%w/w) | |
| AF-1 | 0.5 | — | 4 | 29.56 ± 0.33 | 59.12 ± 0.35 |
| AF-2 | 1.0 | — | 4 | 37.65 ± 0.15 | 75.30 ± 0.56 |
| AF-3 | 1.5 | — | 4 | 44.85 ± 0.28 | 89.70 ± 0.36 |
| AF-4 | 2.0 | — | 4 | 46.65 ± 0.62 | 93.30 ± 0.55 |
| AF-5 | 1.5 | 0.4 | 4 | 45.95 ± 0.12 | 91.90 ± 0.25 |
| AF-6 | 1.5 | 0.6 | 4 | 47.45 ± 0.55 | 94.90 ± 0.55 |
| AF-7 | 1.5 | 1.0 | 4 | 49.25 ± 0.32 | 98.50 ± 0.09 |
| AF-8 | 1.5 | 1.5 | 4 | 49.75 ± 0.25 | 99.50 ± 0.05 |
| AF-9 | 1.5 | 1.0 | 0.5 | 47.30 ± 0.87 | 94.60 ± 0.69 |
| AF-10 | 1.5 | 1.0 | 2 | 46.80 ± 0.74 | 93.60 ± 1.14 |
| AF-11 | 1.5 | 1.0 | 4 | 45.40 ± 0.14 | 91.82 ± 1.04 |
| AF-12 | 1.5 | 1.0 | 6 | 44.60 ± 0.42 | 89.20 ± 1.07 |
All the formulations contain 200 mg of aceclofenac sodium. Data are expressed ± S.D. n = 3.