Table 2.
The list of clinical trials which involve the preparation of tumor cells killed by an ICD-inducing physical modality for the use as whole cell- or DC-based vaccines in cancer immunotherapy
| Indications | Status | Phase | Type of physical modality applied | Notes | Ref. |
|---|---|---|---|---|---|
| Prostate cancer | Recruiting | II | RT | castrate resistant metastatic prostate cancer (CRPC) | NCT01807065 |
| Prostate cancer | Recruiting | II | HHP | After radical primary prostatectomy | NCT02107404 |
| Prostate cancer | Ongoing, recruited | II | HHP | After primary radiotherapy, with high risk | NCT02107430 |
| Prostate cancer | Ongoing, recruited | II | HHP | CRPC combined with docetaxel chemotherapy | NCT02105675 |
| Prostate cancer | Ongoing, recruited | II | HHP | CRPC combined with hormone therapy | NCT02107391 |
| Prostate cancer | Recruiting | II | HHP | 2nd treatment cycle of vaccine in localized cancer | NCT02137746 |
| Prostate cancer | Recruiting | III | HHP | CRPC combined with docetaxel chemotherapy | NCT02111577 |
| Ovarian cancer | Recruiting | II | HHP | Newly diagnosed patients with chemotherapy | NCT02107937 |
| Ovarian cancer | Recruiting | II | HHP | Relapsed platinum resistant ovarian cancer | NCT02107378 |
| Ovarian cancer | Recruiting | II | HHP | Relapsed gemcitabine resistant ovarian cancer | NCT02107950 |
| HNSCC | Trial to be open by 2017 | I | PDT | As adjuvant to surgery for advanced HNSCC | Personal Communication (SO Gollnick, Roswell Park Cancer Institute, USA) |
Abbreviations: CRPC, castrate resistant metastatic prostate cancer; DC, dendritic cells; HHP, high hydrostatic pressure; HNSCC, Head and Neck squamous cell carcinoma; PDT, photodynamic therapy; RT, radiotherapy;