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. 2015 Jan 21;14(2):243–252. doi: 10.4161/15384101.2014.977112

Figure 2.

Figure 2.

miR-146a promoted the expression of inflammatory cytokines associated with STAT3 activation in HCC cells. As described in the Materials and Methods section, HepG2 cells were transfected with negative control RNA (NC), miR-146a mimics (miR146a-Mim), miR-146a inhibitors (miR146a-Inh), or STAT3 decoy ODN (STAT3-Dec). (A) HepG2 proliferation was analyzed by MTT assay at the indicated time points. (B) Cell cycle was determined by flow cytometry. The levels of inflammatory cytokines associated with STAT3 activation were determined by qPCR (C) and ELISA (D) analysis. Data are representative of 3 independent experiments, and statistical significance was determined as **P < 0.01 and *P < 0.05 compared to NC.