Table 1.
Enriched GO cellular component categories of deletion strains sensitive to 5FU. Genes were classified according to GO cellular component categories using STRING database. Note that alp13 and png2 are included in both HAT and HDAC
| Gene Name | Annotationa | Complex | Human orthologb |
|---|---|---|---|
| HAT Complex | |||
| ada2 | Transcriptional adapter 2 | SAGA | TADA2A* |
| alp13 | Chromatin modification-related protein eaf3 | nuA4 | MORF4, MORF4L1, MORF4L2 |
| bdc1 | Bromodomain-containing protein 1 | nuA4 | BRD8 |
| eaf7 | Probable chromatin modification-related protein eaf7 | nuA4 | MRGBP |
| gcn5 | Histone acetyltransferase gcn5 | SAGA | KAT2A, KAT2B |
| ngg1 | Ada histone acetyltransferase complex component | SAGA | TADA3 |
| png2 | Chromatin modification-related protein png2 | nuA4 | ING2, ING3, ING4, ING5 |
| sgf29 | SAGA-associated factor 29 homolog | SAGA | SGF29 |
| spt8 | Transcription factor spt8 | SAGA | |
| spt20 | SAGA complex subunit spt20 | SAGA | SUPT20H, SUPT20HL1, SUPT20HL2 |
| tra1 | Transcription-associated protein 1 | SAGA | TRRAP8* |
| HDAC Complex | |||
| cph2 | Clr6 histone deacetylase associated PHD protein-2 Cph2 | Rpd3 | PHF12* |
| phd1 | Histone deacetylase phd1 | Rpd3 | HDAC1, HDAC2 |
| prw1 | RbAp48-related WD40 repeat-containing protein prw1 | Rpd3 | RBBP4, RBBP7 |
| pst2 | Paired amphipathic helix protein pst2 | Rpd3 | SIN3A, SIN3B |
| set3 | SET domain-containing protein 3 | Rpd3 | KMT2E |
| rxt3 | Transcriptional regulatory protein rxt3 | Rpd3 | CRISPLD2 |
| HMT Complex | |||
| ash2 | Set1 complex component ash2 | Set1C/COMPASS | ASH2L* |
| set1 | Histone-lysine N-methyltransferase, H3 lysine-4 specific | Set1C/COMPASS | SETD1A |
| spp1 | Set1 complex component spp1 | Set1C/COMPASS | CXXC1 |
| swd1 | Set1 complex component swd1 | Set1C/COMPASS | RBBP5* |
| swd3 | Set1 complex component swd3 | Set1C/COMPASS | WDR5 |
| Swr1 Complex | |||
| arp6 | Actin-like protein arp6 | Swr1 | ACTR6* |
| bdf1 | SWR1 complex bromodomain subunit bdf1 | Swr1 | BRD2, BRD3, BRD4, BRDT |
| pht1 | Histone H2A.Z | Swr1 | H2AFV, H2AFZ |
| vps71 | SWR1 complex subunit vps71 | Swr1 | ZNHIT1* |
| swc2 | SWR1 complex protein 2 | Swr1 | VPS72* |
| swc3 | SWR1 complex subunit swc3 | Swr1 | |
| swc5 | SWR1 complex protein 5 | Swr1 | CFDP1 |
| swr1 | Helicase swr1 | Swr1 | SRCAP* |
| Heterochromatin | |||
| brl1 | E3 ubiquitin-protein ligase brl1 | HULC | RNF40 |
| brl2 | E3 ubiquitin-protein ligase brl2 | HULC | RNF20, RNF40 |
| ccq1 | Structural maintenance of chromosomes protein ccq1 | Stn1-Ten1 | |
| clr4 | Histone H3-K9 methyltransferase | CLRC | SUV39H1, SUV39H2 |
| hta1 | Histone H2A-α | H2AFX | |
| mms19 | MMS19 nucleotide excision repair protein homolog | MMS19 | |
| raf1 | Rik1-associated factor 1 | CLRC | |
| rhp6 | Ubiquitin-conjugating enzyme E2 2 | HULC | UBE2B |
| rdp1 | RNA-dependent RNA polymerase 1 | ||
| shf1 | Small histone ubiquitination factor 1 | HULC | PPHLN1 |
| swi6 | Chromatin-associated protein swi6 | CBX1, CBX3, CBX5 | |
| tas3 | RNA-induced transcriptional silencing complex protein tas3 | RITS |
a
Annotation provides a schematically description of the gene product as indicated in UniprotKB database (http://www.uniprot.org/).
b
Potential human ortholog genes found in the databases PomBase or KOG (asterisks).