Schematic representation of CB subdomains and their regulatory states. (A,B) Diagrams of gastrula stage embryo ectodermal regions illustrating the position of the CB subdomains, relative to other select embryonic territories. These diagrams are simplified by omitting territorial subdivisions within the ectoderm (Li et al., 2014). (Aa,b) CB (blue) in lateral and oral views, respectively. (Ba,b) CB subdomains (1-4) and adjacent embryonic territories (color-coded). Lateral and oral views are shown as in A. (C) Regulatory gene expression matrix for CB subdomains and adjacent territories (except for the aboral apical plate, which is not yet completely analyzed) at mid-gastrula. Filled black circles denote gene expression (data from RNA in situ hybridizations). Embryonic territories that correspond to the blue CB areas in A are highlighted in blue.