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. 2015 Mar 1;142(5):910–920. doi: 10.1242/dev.116996

Fig. 6.

Fig. 6.

Epigenetic changes accompanying zygotic pancRNA-mediated gene activation during early mouse development. (A) DNA methylation status of ABA-treated 2-cell embryos. (B) DNA methylation status of Tet2 or Tet3 versus control siRNA-injected embryos. ***P<0.001. (C) A model for pancRNA-mediated gene activation in early mouse development. At the 2-cell stage, pancIl17d expression, together with TET3 and PARP, leads to establishment of the hypomethylated status at the Il17d promoter in a sequence-specific manner, and thus to Il17d mRNA expression starting from the 4-cell stage. When these steps are compromised, apoptosis increases and cell proliferation decreases, adversely affecting embryonic development.