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. 2015 Mar 1;142(5):817–831. doi: 10.1242/dev.105536

Fig. 2.

Fig. 2.

Summary of regionalized gene expression in the growth plate. Schematic representation of the various zones of chondrocyte maturation are displayed for a E15.5-E16.5 mouse long-bone growth plate. The expression of various classes of genes and/or proteins is displayed. Ligands: Fgf9/18 (Liu et al., 2002; Hung et al., 2007), PTHrP (St-Jacques et al., 1999), CNP (Chusho et al., 2001), EGF/TGFα (Ren et al., 1997), Ihh (Vortkamp et al., 1996), VEGFA (Zelzer et al., 2001) and RANKL (Zhang et al., 2011). Receptors: Fgfr1 (Jacob et al., 2006), Fgfr2 (Yu et al., 2003), Fgfr3 (de Frutos et al., 2007), Pth1r (Lee et al., 1996; de Frutos et al., 2007), Npr2 (Yamashita et al., 2000), Npr3 (Yamashita et al., 2000) and Egfr (Zhang et al., 2013). Transcription factors: Sox5/6/9 (Lefebvre et al., 1998), Runx2 (Inada et al., 1999; Kim et al., 1999), Mef2c and Mef2d (Mef2c/d) (Arnold et al., 2007), Foxa2 (Ionescu et al., 2012), and Zfp521 (Correa et al., 2010). Structural proteins: aggrecan (Acan) (Inada et al., 1999), Col2a1 (de Frutos et al., 2007), Col10a1 (de Frutos et al., 2007), Mmp9 and Mmp13 (Mmp9/13) (Inada et al., 1999), and Spp1 (Inada et al., 1999). Others: Hdac4 (Vega et al., 2004), Sik3 (Sasagawa et al., 2012) and reactive oxygen species (ROS) (Morita et al., 2007). For a comprehensive review of the expression pattern of BMP and TGFβ ligands and receptors, see Minina et al. (2005).