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A violin plot showing distribution of the predicted oxopiperazine analogues for their potential to target the CH1 domain of p300/CBP. The binding affinity is expressed as Rosetta binding energy unit (REU). The plot shows the energy scores for the top scoring 1000 designs selected from 30 000 random Rosetta designs (gray violin) as well as experimentally tested designs (dots). The Rosetta score discriminates between good binders (green and yellow label) and weak binders (red label).
