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. 2015 Jan 17;14(2):189–199. doi: 10.4161/15384101.2014.973743

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Main layers of regulation controlling the MST2-Raf-1 network behavior. (A) The core interaction scheme with overlapping regulatory layers. (B) The level and degree of the switches in the network being modulated by Ras, Akt and LATS1. (C) The switch-generating motif in the MST2-Raf-1 network. (D) The switch-generating motif by a single protein. X*, X** and X*** represent different forms of the unmodified protein X.