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Primary Brca1S971A/S971A MEFs are more sensitive than Brca1+/+ MEFs to PARP inhibitor KU-0058948 in p53−/− background. Normal student t-test was used for statistical analysis. p = 0.02, 0.08 and 0.05 for PARPi at 0.1, 1 and 10μM, respectively. p = 0.0008 for overall curves(n = 3).
