Table 3.
Intention to treat analyses of primary and secondary outcomes at four month follow-up in study of integrated primary care for patients with mental and physical multimorbidity
| Intervention | Usual care | Comparison | |||||||
|---|---|---|---|---|---|---|---|---|---|
| No of patients | Mean (SD) | No of patients | Mean (SD) | Adjusted difference in means (95% CI)*, P value | Effect size (95% CI)† | Intracluster coefficient | |||
| Primary outcome | |||||||||
| SCL-D-13 (0-4) | 170 | 1.76 (0.9) | 180 | 2.02 (0.9) | −0.23 (−0.41.to −0.05), 0.01 | −0.30 (−0.54 to −0.07) | 0.03 | ||
| Secondary outcomes | |||||||||
| PHQ-9 (0-27) | 157 | 11.3 (6.5) | 168 | 13.1 (6.5) | −1.2 (−2.37 to −0.03), 0.04 | −0.29 (−0.57 to −0.01) | 0.02 | ||
| GAD-7 (0-21) | 157 | 8.2 (5.8) | 168 | 9.7 (5.9) | −1.45 (−2.45 to −0.56), 0.006 | −0.28 (−0.47 to -0.09) | 0.00 | ||
| ESSI (0-34) | 155 | 3.29 (1.1) | 165 | 3.4 (1.0) | 0.01 (−0.19 to 0.22), 0.91 | 0.01 (−0.18 to 0.20) | 0.07 | ||
| Health education impact questionnaire (heiQ): | |||||||||
| Positive engagement | 155 | 2.48 (1.3) | 164 | 2.32 (1.4) | 0.20 (−0.07 to 0.48), 0.14 | 0.16 (−0.06 to 0.39) | 0.02 | ||
| Health directed behaviour | 155 | 1.92 (1.8) | 164 | 1.65 (1.5) | 0.06 (−0.28 to 0.39), 0.72 | 0.04 (−0.18 to 0.26) | 0.05 | ||
| Skill acquisition | 153 | 2.76 (1.1) | 163 | 2.52 (1.2) | 0.26 (0.02 to 0.50), 0.04 | 0.25 (0.02 to 0.48) | 0.04 | ||
| Constructive attitudes | 155 | 2.83 (1.2) | 165 | 2.64 (1.3) | 0.31 (0.07 to 0.55), 0.01 | 0.25 (0.05 to 0.44) | 0.02 | ||
| Self monitoring | 155 | 3.65 (0.7) | 165 | 3.32 (1.0) | 0.31 (0.01 to 0.52),‡ 0.004 | 0.36 (0.11 to 0.60) | 0.08 | ||
| Health service navigation | 155 | 2.67 (1.0) | 165 | 3.35 (1.2) | 0.28 (0.03 to 0.53), 0.03 | 0.27 (0.03 to 0.52) | 0.06 | ||
| Social integration | 155 | 3.03 (1.3) | 165 | 3.0 (1.4) | −0.01 (−0.32 to 0.31), 0.10 | −0.01 (−0.25 to 0.24) | 0.08 | ||
| Emotional wellbeing | 155 | 2.65 (1.3) | 165 | 3.09 (1.2) | −0.35 (−0.61 to −0.09), 0.01 | −0.32 (−0.55 to −0.08) | 0.05 | ||
| MULTIPleS | 151 | 2.1 (0.9) | 165 | 2.28 (0.9) | −0.14 (−0.34 to 0.06), 0.17 | −0.18 (−0.43 to 0.08) | 0.09 | ||
| SDS (0-10) | 153 | 5.73 (2.8) | 163 | 5.83 (2.8) | −0.27 (−0.75 to 0.20), 0.24 | −0.11 (−0.29 to 0.08) | 0.00 | ||
| SEQ | 155 | 5.72 (1.9) | 166 | 5.54 (1.9) | 0.21 (−0.15 to 0.58), 0.24 | 0.13 (−0.09 to 0.34) | 0.02 | ||
| WHOQOL-BREF | 152 | 2.99 (0.6) | 167 | 2.91 (0.6) | 0.07 (−0.05 to 0.19), 0.26 | 0.13 (−0.10 to 0.36) | 0.02 | ||
ESSI=Enrichd social support inventory; GAD=generalised anxiety disorder assessment; MULTIPleS=multimorbidity illness perception scales; SCL=symptom check list; SEQ=self efficacy questionnaire; SDS=Sheehan disability scale; SCL-D-13=symptom checklist depression scale; WHOQOL-BREF=WHO quality of life measure.
*Analyses with multiple imputation for missing baseline and follow-up data points adjusted for baseline measures of outcome and minimisation variables (practice deprivation and practice size).
†Effect size based on pooled SD of baseline measures.
‡Estimated with bootstrapping.