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. 2015 Mar 9;6:176. doi: 10.3389/fmicb.2015.00176

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Copyright © 2015 Szczepaniak, Łukaszewicz and Krasowska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of ABC transporters Cdr1p and Cdr2p by beauvericin. DiS-C₃(3) was added at the beginning of the experiment and fluorescence was measured every 4 min. Two percent glucose was added to the sample at 60 min and beauvericin at 80 min. (A) Influence of 1 μg/ml beauvericin on diS-C₃(3) staining in C. albicans WT and CDR1ΔCDR2Δ strains. (B) Dose-dependent inhibition of diS-C₃(3) staining by beauvericin on C. albicans CDR1Δ strain. Lower lambda max indicates more probe transported out of the cells. (C) Dose-dependent inhibition of diS-C₃(3) staining by beauvericin on C. albicans CDR2Δ strain.