Table 3.

Enzyme substrate promiscuity indices

Enzymeb	Standard Index of substrate promiscuity (I)ac				Weighted Index of substrate promiscuity (J)ac
	I	I-ValP	I-Pyr	I-P5C	J	J-ValP	J-Pyr	J-P5C
Cgl	0.71	0.57	0.74	0.75	0.61	0.39	0.61	0.69
Spr	0.67	0.71	0.70	0.70	0.59	0.67	0.60	0.64
Svi1	0.67	0.62	0.70	0.70	0.59	0.59	0.60	0.63
Svi2	0.47	0.81	0.49	0.49	0.42	0.79	0.43	0.46
Sgr	0.65	0.66	0.68	0.67	0.57	0.64	0.58	0.61
Sav	0.70	0.77	0.73	0.73	0.62	0.74	0.64	0.67
Sam	0.74	0.66	0.77	0.77	0.66	0.64	0.66	0.70
Sco2	0.83	0.75	0.83	0.83	0.77	0.73	0.76	0.83
Sli2	0.80	0.71	0.83	0.83	0.75	0.70	0.75	0.78
Sco1	0.64	0.42	0.67	0.67	0.56	0.40	0.57	0.61
Sli1	0.64	0.51	0.67	0.67	0.56	0.48	0.56	0.60
Sco_P5CR	0	0	0	0	0	0	0	0

^aBoth indices range between 0 and 1.

^bEnzyme nomenclature is as in Table 1.

^cN, number of substrates; e, catalytic efficiency; δ_i = δ_ij / δ_set, δ_ij, the mean Tanimoto distance from a member i to all the other members in the set; δ_set, the overall set dissimilarity.