Figure 7.

Figure Ca²⁺ binding appears to promote structural changes in the loops of the PLAT domain. (A) Superposition of cartoon renderings of 8R-LOX (light blue) and 15-LOX-2 structures (flesh), both in the presence of Ca²⁺. Three Ca²⁺ (spheres) sites are found in the former, and two in the latter. (B) Superposition of 8R-LOX in the presence of Ca²⁺ and 11-R-LOX in its absence. Despite a higher sequence identity in this pair of LOX, the loop conformations are divergent, presumably a reflection of differences in the Ca²⁺-bound- and Ca²⁺-free states.