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Crystal structure of the AFPDZ–nectin-3 C-terminal peptide complex. (A) Domain architecture of l-afadin and nectin-3. The AFPDZ interacts with the nectin-3 C-terminus. RA, Ras-association; FHA, forkhead-associated; DIL, dilute; PR, proline-rich region; Ig, immunoglobulin-like; TM, transmembrane region. (B) Overall structure of AFPDZ–nectin-3 complex. (C) Close-up view of the monomeric AFPDZ–nectin-3 fusion protein structure.
