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The Role of SIRT1 in synaptic plasticity. SIRT1 modulates synaptic plasticity through the regulation of BDNF. The SIRT1 and YY1 complex limits the expression of miR-134 which affects the CREB-BDNF axis (A) and leading to enhanced Limk1 protein synthesis (B). The release of BDNF activates mTOR signaling pathway which suppress miR-134 activity. MeCP2 deacetylation by SIRT1 could also promote BDNF transcription (C).
