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. Author manuscript; available in PMC: 2015 May 20.
Published in final edited form as: Nature. 2014 Sep 17;515(7527):423–426. doi: 10.1038/nature13738

Figure 2. R. obeum AI-2 reduces V. cholerae colonization and virulence gene expression.

Figure 2

(a) R. obeum AI-2 produced in E. coli represses the tcp promoter in V. cholerae (triplicate assays; results representative of four independent experiments). (b) Fecal V. cholerae levels in gnotobiotic mice 8h after gavage with V. cholerae and an E. coli strain containing either the PBAD-R. obeum luxS plasmid or vector control. (c) Fecal vqmA transcript abundance in mono- or co-colonized mice. (d) Competitive index of ΔvqmA versus wild-type V. cholerae during co-colonization with R. obeum (n=5 animals/group). Mean values±SEM are shown. *, P<0.05, **, P<0.01, ****, P<0.0001 (unpaired two-tailed Student’s t-test).