Table 4.
Correlation between SNCA and FBN1 hypermethylation status in stool DNA of CRC patients and clinicopathological parameters.
| Parameters | Number of cases | SNCA | FBN1 | ||
|---|---|---|---|---|---|
| Methylation | P value | Methylation | P value | ||
| Age | |||||
| <50 | 24 | 17 (70.8%) | 0.958a | 19 (79.2%) | 0.173a |
| 50–60 | 24 | 18 (75.0%) | 17 (70.8%) | ||
| 60–70 | 22 | 15 (68.2%) | 15 (68.2%) | ||
| >70 | 19 | 14 (73.7%) | 18 (94.7%) | ||
| Gender | |||||
| Male | 54 | 38 (70.4%) | 0.688a | 41 (75.9%) | 0.653a |
| Female | 35 | 26 (74.3%) | 28 (80.0%) | ||
| Tumor location | |||||
| Left hemicolon | 19 | 13 (68.4%) | 0.470a | 17 (89.5%) | 0.255a |
| Transverse colon | 5 | 4 (80.0%) | 5 (100%) | ||
| Right hemicolon | 8 | 4 (50.0%) | 6 (75.0%) | ||
| Rectum | 57 | 43 (75.4%) | 41 (71.9%) | ||
| Pathological pattern | |||||
| Ulcerative type | 60 | 42 (70.0%) | 0.581a | 46 (76.7%) | 0.504a |
| Protrude type | 24 | 19 (79.2%) | 20 (83.3%) | ||
| Infiltrating type | 5 | 3 (60.0%) | 3 (60.0%) | ||
| Dukes' stage | |||||
| A | 17 | 11 (64.7%) | 0.323a | 13 (76.5%) | 0.237a |
| B | 36 | 29 (80.6%) | 25 (69.4%) | ||
| C | 36 | 24 (66.7%) | 31 (94.4%) | ||
aUsing chi-square for this statistic.