Table 2.
Homology (%) of amino acids and nucleotides among MiIFN-α subtypes
| IFN-α1 | IFN-α2 | IFN-α3 | IFN-α4 | IFN-α5 | IFN-α6 | IFN-α7 | IFN-α8 | IFN-α9 | IFN-α10 | IFN-α11 | IFN-α12 | IFN-α13 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IFN-α1 | - | 99.3 | 97.0 | 95.0 | 96.3 | 94.5 | 94.7 | 94.7 | 93.8 | 94.7 | 94.3 | 96.1 | 95.4 |
| IFN-α2 | 98.4 | - | 96.6 | 95.7 | 97.0 | 95.2 | 94.7 | 94.9 | 94.0 | 94.3 | 94.0 | 95.7 | 95.0 |
| IFN-α3 | 94.7 | 94.1 | - | 96.3 | 96.8 | 94.7 | 96.3 | 96.6 | 95.7 | 96.3 | 95.2 | 98.0 | 95.6 |
| IFN-α4 | 90.4 | 92.0 | 93.0 | - | 98.8 | 98.4 | 96.5 | 96.3 | 95.4 | 96.6 | 95.0 | 95.7 | 96.1 |
| IFN-α5 | 93.0 | 94.7 | 93.6 | 97.3 | - | 97.2 | 97.0 | 96.1 | 95.2 | 97.0 | 95.6 | 95.6 | 96.1 |
| IFN-α6 | 89.3 | 90.9 | 91.4 | 98.4 | 95.7 | - | 95.2 | 95.0 | 94.3 | 95.0 | 96.3 | 94.7 | 95.6 |
| IFN-α7 | 91.4 | 90.9 | 93.0 | 93.6 | 94.1 | 92.5 | - | 96.8 | 96.3 | 97.9 | 97.2 | 95.2 | 96.3 |
| IFN-α8 | 90.9 | 90.9 | 94.1 | 92.5 | 92.0 | 91.4 | 94.1 | - | 99.1 | 95.9 | 94.3 | 97.3 | 95.6 |
| IFN-α9 | 89.3 | 89.3 | 92.5 | 90.9 | 90.4 | 89.8 | 93.6 | 98.4 | - | 95.0 | 93.6 | 96.5 | 94.7 |
| IFN-α10 | 91.4 | 90.9 | 94.1 | 94.7 | 95.2 | 93.0 | 96.8 | 92.0 | 90.4 | - | 97.2 | 96.3 | 96.3 |
| IFN-α11 | 89.8 | 89.3 | 92.0 | 92.5 | 93.0 | 94.1 | 95.2 | 90.4 | 88.8 | 96.8 | - | 94.9 | 95.7 |
| IFN-α12 | 93.0 | 92.5 | 97.3 | 92.5 | 92.0 | 91.4 | 92.0 | 95.2 | 93.6 | 93.6 | 92.0 | - | 95.6 |
| IFN-α13 | 91.4 | 90.9 | 91.4 | 92.0 | 92.5 | 91.4 | 93.6 | 90.4 | 88.8 | 93.6 | 93.0 | 90.4 | - |
“–” same sequence. The upper line shows identities at the nucleotide level; The lower line shows identities at the amino acid level. The sequences for alignment were from the following GenBank accession numbers: IFN-α1(MiIFN-α1, EU863613), IFN-α2 (MiIFN-α2, EU863614), IFN-α3 (MiIFN-α3, EU863615), IFN-α4 (MiIFN-α4, EU863616), IFN-α5 (MiIFN-α5, EU863617), IFN-α6 (MiIFN-α6, EU863618), IFN-α7(MiIFN-α7, EU863619), IFN-α8 (MiIFN-α8, EU863620), IFN-α9 (MiIFN-α9, EU863621), IFN-α10 (MiIFN-α10, EU863622), IFN-α11 (MiIFN-α11, EU863623), IFN-α12 (MiIFN-α12, EU863624), IFN-α13 (MiIFN-α13, EU091340).