Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan 31;3:8. doi: 10.1186/s40478-015-0186-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Blair et al.; licensee BioMed central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

BBB breakdown correlates best with perivascular tau levels. Representative schematic depicting the timeline of progressive pathologies found in rTg4510 mice including tau accumulation, neuronal loss, tau tangle deposition, inflammation, appearance of perivascular tau, and initiation of increased BBB permeability. Tau accumulation begins at a very young age, before one month, followed by regional neuronal loss. A few months after tau tangles start to deposit just after signs of inflammation are noticeable. Neuron loss continues to get more severe with age and by 9 months vascular tau is detectable in the hippocampus, concomitant with the start of increased BBB permeability.