Table 1.

rs10967976 genotype analysis in the Manchester FTLD cohort

rs10967976	Controls (%)	FTD all (%)	OR	95% CI	p	FTD and/or MND (%)	OR	95% CI	p
All cases
AA	164 (26.54)	106 (24.20)	1.0	—		11 (16.92)	1.0	—
GA	330 (53.40)	217 (49.54)	1.01	0.75–1.37	0.91	34 (52.31)	1.53	0.75–3.10	0.233
GG	124 (20.06)	115 (26.26)	1.43	1.00–2.04	0.045	20 (30.77)	2.40	1.11–5.20	0.026
GA + GG	454 (73.46)	332 (75.80)	1.13	0.85–1.50	0.86	54 (83.08)	1.77	0.90–3.47	0.095
AA + GA	494 (79.94)	323 (73.74)	1.0	—		45 (69.23)	1.0
GG	124 (20.06)	115 (26.26)	1.42	1.06–1.89	0.016	20 (30.77)	1.81	1.00–3.10	0.046
Drop “old” expansion cases
AA	164 (26.54)	103 (25.69)	1.0			11 (21.15)	1.0
GA	330 (53.40)	200 (49.88)	0.96	0.71–1.30	0.817	25 (48.08)	1.12	0.54–2.35	0.745
GG	124 (20.06)	98 (24.44)	1.26	0.87–1.80	0.213	16 (30.77)	1.92	0.86–4.29	0.110
GA + GG	454 (73.46)	298 (74.31)	1.04	0.78–1.39	0.763	41 (78.85)	1.34	0.67–2.68	0.398
AA + GA	494 (79.94)	303 (75.56)	1.0			36 (69.23)	1.0
GG	124 (20.06)	99 (24.44)	1.28	0.95–1.74	0.099	16 (30.77)	1.77	0.95–3.29	0.071
Drop “old” and “new” expansion cases
AA	164 (26.54)	100 (25.64)	1.0			10 (20.41)	1.0
GA	330 (53.40)	198 (50.77)	0.98	0.72–1.33	0.917	25 (51.02)	1.24	0.58–2.64	0.574
GG	124 (20.06)	92 (23.59)	1.21	0.84–1.75	0.295	14 (28.57)	1.85	0.79–4.30	0.153
GA + GG	454 (73.46)	290 (74.36)	1.04	0.78–1.39	0.768	39 (79.59)	1.40	0.68–2.88	0.349
AA + GA	494 (79.94)	298 (76.41)	1.0			35 (71.43)	1.0
GG	124 (20.06)	92 (23.59)	1.22	0.90–1.66	0.184	14 (28.57)	1.59	0.83–3.20	0.160

Key: CI, confidence interval; FTD, frontotemporal dementia; FTLD, frontotemporal lobar degeneration; OR, odds ratio.