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Impact of VIP-deficiency on circulating estradiol and ovulation in adult females. A. The proestrus mid-day increase in serum estradiol is not affected by the loss of VIP in female mice. B. The number of oocytes spontaneously released on the morning of estrus is reduced in VIP−/− oviducts compared to WT (* P = 0.002) C. The number of oocytes released in response to PMSG-hCG ovarian stimulation technique in hormone-primed female mice was not different between the genotypes.
