Fig. 5.
Impact of the loss of VIP on the amplitude and phasing of PER2::LUC bioluminescence in female SCN and peripheral organs. A. Representative bioluminescence rhythms from WT and VIP−/− SCN ex vivo culture. B. Phases of peak expression of PER2::LUC of the pituitary and the uterus are altered in the VIP-deficient mice when compared to WT controls (* P < 0.05). C. Amplitude of PER2::LUC bioluminescence in SCN and pituitary are dependent on VIP (* P < 0.05), while the amplitude of the ovary and uterus are unaltered.