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. 2015 Mar 8;12:9. doi: 10.1186/s12986-015-0005-6

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© Yang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Insulin secretion during a hyperglycemic clamp. Hyperglycemic clamp was conducted in conscious, free moving, and overnight fasted rats to measure glucose-stimulated insulin secretion. As exogenous glucose was infused into jugular vein to make approximately 5.5 mM above overnight fasted serum glucose levels, serum insulin levels were measured at 0, 2, 5, 10, 30, 60, 90 and 120 mins. The β-amyloid (25–35) infused diabetic rats fed high fat diets with 1% dextrin (AD-CON), 1% less pungent red pepper (AD-LSP), moderate pungent red pepper (AD-MSP) or severe pungent red pepper (AD-SSP) for 28 days. The β-amyloid (35–25) infused rats fed high fat diets with 1% dextrin (Non-AD-CON). Each dot represents Means ± SD (n = 10). *Significantly different among the groups at P < 0.05.