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. 2015 Mar;265:48–58. doi: 10.1016/j.expneurol.2014.11.013

Fig. 5.

Fig. 5

OR memory deficit returns 5 weeks after ChABC treatment in Tg P301S mice PNNs were visualized by WFA staining in P-nase (A) or ChABC (B) injected mice 5 weeks post-injection. The PNNs present in the PRh of P-nase (a) or ChABC (b) injected mice were shown at higher magnification. C. Stereological quantification of WFA-positive cells in the PRh of P301S mice following P-nase (n = 5) or ChABC (n = 5) injection. There was no significant difference between groups (t-test, n.s: not significant, p = 0.072). D. ChABC and P-nase treated P301S mice showed similar level of deficit 5 weeks following ChABC injection. At this time point, ChABC treatment was no longer effective in restoring the OR memory in Tg P301S mice (P-nase n = 7, ChABC n = 6, t-test, n.s, p = 0.91). E. The exploration time for sample phase of control and P301S mice at 5 weeks after ChABC injection, indicating that each group presented comparable extent of motivation and that lack of motivation was not interfering with the results. Control; P-nase n = 6, ChABC n = 5, P301S; P-nase n = 7, ChABC n = 6.