Figure 6.

Structure of P1aABD/β4Fn12 Complex

(A) Schematic illustrations of integrin β4 and P1a fragments used in the experiments (boxed areas).

(B) The crystal structure of the P1aABD_Δ22/β4Fn12 complex is shown in two orientations. β4Fn12 is displayed in cyan, and the CH1 and CH2 of the P1aABD_Δ22 are displayed in bronze and orange, respectively. The binding interface comprises three salt bridges between P1a and integrin β4; D123/R1225 (2.60 Å), R71/E1242 (3.04 Å), and E68/R1281 (2.57 Å).

see also Figures S7 and S8; Table S2.