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. 2015 Mar 9;10(3):e0118692. doi: 10.1371/journal.pone.0118692

Fig 1. Summary of the brain data MRI acquisition and processing.

Fig 1

A. (1) Sodium MRI acquisition with and without IR, and proton DIR acquisition. (2) Linear regression of reference phantoms signals. (3) Calculation of aTSC and aISC maps. (4) Calculation of the masks of GM, WM and full brain (GM+WM) from DIR data. (5) Multiplication of sodium maps by the masks. B. Three-compartment model: compartment 1 = intracellular space of volume V1 and sodium concentration C1; compartment 2 = extracellular space of volume V2, sodium concentration C2 and extracellular volume fraction α; compartment 3 = solid compartment of volume Vs and no sodium. Total volume is Vt = V1+ V2 +Vs. Water volume fraction is denoted w. C. C1 and α maps in full brain, GM, and WM calculated from aTSC, aISC and the 3-compartment model. D. Histograms of C1 and α values over the whole full brain, whole GM and whole WM data. GM = gray matter, WM = white matter, GM+WM = full brain. Reproduced from Figs. 1–4 from Ref. [23].