Table 2. Adverse Events.

Author	Adverse events	Possible drug-related events	Dropout
Sima [9]	No increased adverse events had been reported in ALC groups of both RCTs.	Non-reported	No safety dropouts and 9 drug-unrelated deaths were reported in both RCTs.
De Grandis [10]	No significant difference was reported between the ALC and placebo group.	Possibly or probably drug-related adverse events included headache, facial paraesthesia, nausea, retching, biliary colic, vomiting, epigastric pain, and gastrointestinal disorders.	Six patients in the ALC group and 2 in the placebo group dropped out as a consequence of adverse events.
Youle [11]	Nine patients (20.9%) in the ALC group and 14 patients (29.8%) in the placebo group experienced 16 and 20 adverse events, respectively. One drug-unrelated serious adverse event was reported in either group.	Possible drug related events included paraesthesia, pain, anorexia, dry mouth, and neuropathy.	Two patients in ALC group and 6 in placebo group dropped out. Only 1 in ALC group dropped out due to adverse event.

ALC = acetyl-l-Carnitine; RCT = randomized controlled trial.