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. 2015 Mar 9;10(3):e0121441. doi: 10.1371/journal.pone.0121441

Fig 2. The phosphorylation status of receptor tyrosine kinases and cellular kinases in control plasmid and SOD3 transfected cells.

Fig 2

(a,b) A receptor tyrosine kinase phosho-array showed increased levels of phosphorylation of FLT-3, EGFR, ERBB2, RYK, ALK, and EPHA10 in the 8505c SOD3 cells while HGFR activation was downregulated. Note, c-RET is not expressed in 8505c cells and therefore the signal represents unspecific labeling (S1 Fig.). (c,d) Kinase phosphoarray for cytosolic non-receptor kinases and other signaling molecules. SOD3 over-expression increased the activation of CREB, TOR, AKT, GSK3α/β, CHK2, and SCR family members SRC, FYN, YES, HCK, and LYN. Additionally, SOD3 induced β-catenin production. (e) A schematic representation of the main pathways that are affected by robust SOD3 over-expression.