Fig 5. Metabolite correlation network of the endoscopy collected (A) and home collected (B) fecal VOC metabolomes.

Pearson’s correlation coefficients were calculated for metabolites present in 80% or greater of the total fecal samples. A Pearson correlation value greater than 0.95 is depicted as a green line between metabolites (negative correlations are not shown, as correlation values less than-0.95 were not obtained). To facilitate comparison of the networks, metabolites are numerically represented and their placement around the circumference of each network is fixed among the paired plots. Regardless of the fecal collection method used, the fecal samples from the alcoholic participants have a notably different correlation network than that seen in the fecal samples from non-alcoholics. This difference is even more apparent in correlation networks derived using metabolites present in ≥21% of all fecal samples (S2 Fig.).