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. Author manuscript; available in PMC: 2015 Mar 10.
Published in final edited form as: Stem Cells. 2011 Aug;29(8):1241–1255. doi: 10.1002/stem.670

Figure 7.

Figure 7

Recombinant bone morphogenetic protein-2 (BMP-2) “rescues’ human adipose-derived stromal cell (hASC) mediated healing among defects with disrupted dura mater (DM)-hASC interaction. (A): Micro–X-ray computed tomography (micro-CT) CT images of defect sites at stratified time points postoperatively. DM was either left intact or removed at the defect site. Scaffolds were loaded with (200 µg) BMP-2 or phosphate-buffered saline control and engrafted with hASCs. From top to bottom, defects were treated with (a) a BMP-2 releasing scaffold with no hASCs (DM intact) for control purposes, (b) an hASC-engrafted scaffold (DM intact), (c) an hASC-engrafted BMP-2 releasing scaffold (DM intact), or (d) an hASC-engrafted BMP-2 releasing scaffold following DM removal. (B): Healing was quantified by micro-CT and Adobe Photoshop analysis, expressed as average fraction osseous healing of the original defect size. A one-factor analysis of variance was used to compare the different treatment groups, followed by a post hoc student’s t test to assess significance, n = 3; *, p < .05. Abbreviations: ASC, adipose-derived stromal cell; BMP-2, bone morphogenetic protein-2.