Table I.
Main characteristics of the studies included.
| First author, year (ref.) | Country | TP/FP/FN/TN results (n/n/n/n) | Assay type | Cutoff value | HCC/cirrhosis/hepatitis/healthy/others (n/n/n/n/n) |
|---|---|---|---|---|---|
| Hu, 2010 (19) | China | 24/15/7/78 | Western blotting | 7.4 RU | 31/31/31/31/b |
| Mao, 2010 (20) | China/USA | 589/89/200/3339 | Immunoblotting | 8.5 RU | 789/512/337/1690/889 |
| Marrero, 2005 (21) | China | 99/21/45/131 | Immunoblotting | 10 RU | 144/152/b/56/b |
| Morota, 2011 (22) | USA | 62/61/8/98 | ELISA | 94.7 μg/l | 70/35/52/72/b |
| Shi, 2011 (23) | China | 50/5/23/102 | ELISA | 123.2 μg/l | 73/13/32/62/b |
| Tian, 2011 (24) | China | 115/46/38/49 | ELISA | 113.89 μg/l | 153/95/115/109/b |
| Wang, 2009 (25) | USA | 156/64/8/49 | ELISA | NK | 164/113/b/b/b |
| Xu, 2011 (26) | China | 63/38/18/208 | ELISA | NK | 81/176a/40/b |
| Zhao, 2010 (27) | China | 168/41/51/112 | ELISA | 100 ng/ml | 219/110a/43/b |
| Wang, 2013 (28) | China | 62/32/22/141 | Immunoblotting | 8.5 RU | 84/80/32/61/b |
| Hou, 2013 (29) | China | 58/16/21/58 | ELISA | 78.1 ng/l | 84/80/32/61/b |
a
Data including both cirrhosis and chronic hepatitis.
b
No data in this category.
HCC, hepatocellular carcinoma; RU, relative unit; TP, true-positive; FP, false-positive; FN, false-negative; TN, true-negative, NK, not known.