Table III.
Stratified analysis of excision repair cross-complementation group 1 expression with overall survival.
| Variables | na | Pooled HR (95% CI) | Heterogeneity test | Meta-regression P-value | |||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Fixed | Random | Q | P-valueb | I2 (%) | |||
| Location | 0.759 | ||||||
| Asian | 11 | 1.38 (1.19, 1.59) | 1.54 (0.99, 2.38) | 75.37 | <0.001 | 86.7 | |
| Non-Asian | 4 | 1.28 (0.88, 1.86) | 1.31 (0.63, 2.75) | 10.81 | 0.013 | 72.3 | |
| Method | 0.044 | ||||||
| IHC | 10 | 0.99 (0.82, 1.21) | 1.09 (0.69, 1.72) | 44.58 | <0.001 | 79.8 | |
| RT-RCR | 5 | 1.82 (1.51, 2.20) | 2.57 (1.49, 4.45) | 22.78 | <0.001 | 82.4 | |
| Sample size | 0.262 | ||||||
| <100 | 11 | 1.72 (1.39, 2.14) | 1.74 (1.08, 2.80) | 47.53 | <0.001 | 79.0 | |
| ≥100 | 4 | 1.16 (0.97, 1.39) | 1.02 (0.55, 1.91) | 31.14 | <0.001 | 90.4 | |
| HR estimated | 0.304 | ||||||
| Directly obtained | 10 | 1.50 (1.28, 1.76) | 1.73 (1.13, 2.64) | 52.25 | <0.001 | 82.8 | |
| Indirectly obtained | 5 | 1.02 (0.77, 1.34) | 1.08 (0.51, 2.29) | 28.27 | <0.001 | 85.9 | |
| Quality score | 0.177 | ||||||
| 5–6 | 8 | 0.98 (0.78, 1.22) | 1.12 (0.66, 1.89) | 36.49 | <0.001 | 80.8 | |
| 7–8 | 7 | 1.68 (1.41, 2.00) | 1.99 (1.22, 3.26) | 35.66 | <0.001 | 83.2 | |
a
Number of comparisons.
b
P-value of Q-test for heterogeneity test.
IHC, immunohistochemistry; RT-PCR, reverse transcription-polymerase chain reaction; HR, hazard ratio.