Figure 3.

Active component treatment reduces Aβ plaque formation in the APP/PS1 mouse brain. (A) Micrographs of prepared brain tissue display Aβ-positive plaques in the transgenic mouse brain. Fewer Aβ plaques were observed in the active component and DFO group mice compared with the AD model group mice. No Aβ plaques were detected in the C57 group mice. (B) Quantification of Aβ plaques indicated that the number of (left) and area covered by (right) the Aβ plaques were reduced in the active component and DFO group mice compared with the AD model group mice (n=10 per group). ^*P<0.01 vs. C57 and ^#P<0.01 vs. AD model groups. AD, Alzheimer’s disease; DFO, deferoxamine; Aβ, β-amyloid.